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The compiler flag has been added to CFLAGS_NODIST and LDFLAGS_NODIST. This will compile the core interpreter and the stdlib modules with -fno-semantic-interposition but will not affect user build and rpm C extension modules compiled by distutils. This has the effect of speeding up the interpreter up to 27%, depending on the workload, with the drawback of disabling the capability of using LD_PRELOAD to override symbols in libpython. https://fedoraproject.org/wiki/Changes/PythonNoSemanticInterpositionSpeedup