diff --git a/00376-remove-ac_c_char_unsigned-__char_unsigned__.patch b/00376-remove-ac_c_char_unsigned-__char_unsigned__.patch
new file mode 100644
index 0000000..cd2acd2
--- /dev/null
+++ b/00376-remove-ac_c_char_unsigned-__char_unsigned__.patch
@@ -0,0 +1,113 @@
+From 0000000000000000000000000000000000000000 Mon Sep 17 00:00:00 2001
+From: Christian Heimes <christian@python.org>
+Date: Wed, 26 Jan 2022 13:20:31 +0200
+Subject: [PATCH] 00376: Remove AC_C_CHAR_UNSIGNED / __CHAR_UNSIGNED__
+
+Co-authored-by: Christian Heimes <christian@python.org>
+---
+ .../2022-01-25-12-32-37.bpo-46513.mPm9B4.rst  |  2 ++
+ Modules/audioop.c                             |  7 ----
+ configure                                     | 33 -------------------
+ configure.ac                                  |  1 -
+ pyconfig.h.in                                 |  5 ---
+ 5 files changed, 2 insertions(+), 46 deletions(-)
+ create mode 100644 Misc/NEWS.d/next/Build/2022-01-25-12-32-37.bpo-46513.mPm9B4.rst
+
+diff --git a/Misc/NEWS.d/next/Build/2022-01-25-12-32-37.bpo-46513.mPm9B4.rst b/Misc/NEWS.d/next/Build/2022-01-25-12-32-37.bpo-46513.mPm9B4.rst
+new file mode 100644
+index 0000000000..b8986ae31a
+--- /dev/null
++++ b/Misc/NEWS.d/next/Build/2022-01-25-12-32-37.bpo-46513.mPm9B4.rst
+@@ -0,0 +1,2 @@
++:program:`configure` no longer uses ``AC_C_CHAR_UNSIGNED`` macro and
++``pyconfig.h`` no longer defines reserved symbol ``__CHAR_UNSIGNED__``.
+diff --git a/Modules/audioop.c b/Modules/audioop.c
+index 3aeb6f04f1..2a5d805c05 100644
+--- a/Modules/audioop.c
++++ b/Modules/audioop.c
+@@ -5,13 +5,6 @@
+ 
+ #include "Python.h"
+ 
+-#if defined(__CHAR_UNSIGNED__)
+-#if defined(signed)
+-/* This module currently does not work on systems where only unsigned
+-   characters are available.  Take it out of Setup.  Sorry. */
+-#endif
+-#endif
+-
+ static const int maxvals[] = {0, 0x7F, 0x7FFF, 0x7FFFFF, 0x7FFFFFFF};
+ /* -1 trick is needed on Windows to support -0x80000000 without a warning */
+ static const int minvals[] = {0, -0x80, -0x8000, -0x800000, -0x7FFFFFFF-1};
+diff --git a/configure b/configure
+index a7d2975f1f..e68e00b0b3 100755
+--- a/configure
++++ b/configure
+@@ -14183,39 +14183,6 @@ fi
+ 
+ # checks for compiler characteristics
+ 
+-{ $as_echo "$as_me:${as_lineno-$LINENO}: checking whether char is unsigned" >&5
+-$as_echo_n "checking whether char is unsigned... " >&6; }
+-if ${ac_cv_c_char_unsigned+:} false; then :
+-  $as_echo_n "(cached) " >&6
+-else
+-  cat confdefs.h - <<_ACEOF >conftest.$ac_ext
+-/* end confdefs.h.  */
+-$ac_includes_default
+-int
+-main ()
+-{
+-static int test_array [1 - 2 * !(((char) -1) < 0)];
+-test_array [0] = 0;
+-return test_array [0];
+-
+-  ;
+-  return 0;
+-}
+-_ACEOF
+-if ac_fn_c_try_compile "$LINENO"; then :
+-  ac_cv_c_char_unsigned=no
+-else
+-  ac_cv_c_char_unsigned=yes
+-fi
+-rm -f core conftest.err conftest.$ac_objext conftest.$ac_ext
+-fi
+-{ $as_echo "$as_me:${as_lineno-$LINENO}: result: $ac_cv_c_char_unsigned" >&5
+-$as_echo "$ac_cv_c_char_unsigned" >&6; }
+-if test $ac_cv_c_char_unsigned = yes && test "$GCC" != yes; then
+-  $as_echo "#define __CHAR_UNSIGNED__ 1" >>confdefs.h
+-
+-fi
+-
+ { $as_echo "$as_me:${as_lineno-$LINENO}: checking for an ANSI C-conforming const" >&5
+ $as_echo_n "checking for an ANSI C-conforming const... " >&6; }
+ if ${ac_cv_c_const+:} false; then :
+diff --git a/configure.ac b/configure.ac
+index 5aa91cbad3..0efeb8f585 100644
+--- a/configure.ac
++++ b/configure.ac
+@@ -4322,7 +4322,6 @@ fi
+ 
+ # checks for compiler characteristics
+ 
+-AC_C_CHAR_UNSIGNED
+ AC_C_CONST
+ 
+ works=no
+diff --git a/pyconfig.h.in b/pyconfig.h.in
+index b97b8f8bf8..8a4aeda646 100644
+--- a/pyconfig.h.in
++++ b/pyconfig.h.in
+@@ -1656,11 +1656,6 @@
+ /* Define on FreeBSD to activate all library features */
+ #undef __BSD_VISIBLE
+ 
+-/* Define to 1 if type `char' is unsigned and you are not using gcc.  */
+-#ifndef __CHAR_UNSIGNED__
+-# undef __CHAR_UNSIGNED__
+-#endif
+-
+ /* Define to 'long' if <time.h> doesn't define. */
+ #undef clock_t
+ 
diff --git a/python3.10.spec b/python3.10.spec
index cc2c635..636c32a 100644
--- a/python3.10.spec
+++ b/python3.10.spec
@@ -17,7 +17,7 @@ URL: https://www.python.org/
 #global prerel ...
 %global upstream_version %{general_version}%{?prerel}
 Version: %{general_version}%{?prerel:~%{prerel}}
-Release: 2%{?dist}
+Release: 3%{?dist}
 License: Python
 
 
@@ -312,6 +312,10 @@ Patch328: 00328-pyc-timestamp-invalidation-mode.patch
 # https://github.com/GrahamDumpleton/mod_wsgi/issues/730
 Patch371: 00371-revert-bpo-1596321-fix-threading-_shutdown-for-the-main-thread-gh-28549-gh-28589.patch
 
+# 00376 # 9fecd19d88858a4a5ff753c9c91e857c897ff47a
+# Remove AC_C_CHAR_UNSIGNED / __CHAR_UNSIGNED__
+Patch376: 00376-remove-ac_c_char_unsigned-__char_unsigned__.patch
+
 # (New patches go here ^^^)
 #
 # When adding new patches to "python" and "python3" in Fedora, EL, etc.,
@@ -1607,6 +1611,10 @@ CheckPython optimized
 # ======================================================
 
 %changelog
+* Tue Feb 01 2022 Tomáš Hrnčiar <thrnciar@redhat.com> - 3.10.2-3
+- Backport AC_C_CHAR_UNSIGNED/__CHAR_UNSIGNED__ removal
+- Fixes: rhbz#2043555
+
 * Fri Jan 21 2022 Fedora Release Engineering <releng@fedoraproject.org> - 3.10.2-2
 - Rebuilt for https://fedoraproject.org/wiki/Fedora_36_Mass_Rebuild