diff --git a/macros.python-srpm b/macros.python-srpm
index f115a85..dcc7023 100644
--- a/macros.python-srpm
+++ b/macros.python-srpm
@@ -49,6 +49,20 @@
 # Alternatively, it can be overridden in spec (e.g. to "3.8") when building for alternate Python stacks.
 %python3_pkgversion 3
 
+# Define where Python wheels will be stored and the prefix of -wheel packages
+# - In Fedora we want wheel subpackages named e.g. `python-pip-wheel` that
+#   install packages into `/usr/share/python-wheels`. Both names are not
+#   versioned, because they're used by all Python 3 stacks.
+# - In RHEL we want wheel packages named e.g. `python3-pip-wheel` and
+#   `python3.11-pip-wheel` that install packages into similarly versioned
+#   locations. We want each Python stack in RHEL to have their own wheels,
+#   because the main python3 wheels (which we can't upgrade) will likely be
+#   quite old by the time we're adding new alternate Python stacks.
+# - In ELN we want to follow Fedora, because builds for ELN and Fedora rawhide
+#   need to be interoperable.
+%python_wheel_pkg_prefix python%{?rhel:%{!?eln:%{python3_pkgversion}}}
+%python_wheel_dir %{_datadir}/%{python_wheel_pkg_prefix}-wheels
+
 
 ### BRP scripts (and related macros)
 
diff --git a/python-rpm-macros.spec b/python-rpm-macros.spec
index 13d87d1..0b73c3b 100644
--- a/python-rpm-macros.spec
+++ b/python-rpm-macros.spec
@@ -47,7 +47,7 @@ elseif posix.stat('macros.python-srpm') then
 end
 }
 Version:        %{__default_python3_version}
-Release:        10%{?dist}
+Release:        11%{?dist}
 
 BuildArch:      noarch
 
@@ -141,6 +141,9 @@ install -m 755 brp-* %{buildroot}%{_rpmconfigdir}/redhat/
 
 
 %changelog
+* Wed Oct 20 2021 Tomas Orsava <torsava@redhat.com> - 3.10-11
+- Define a new macros %%python_wheel_dir and %%python_wheel_pkg_prefix
+
 * Tue Oct 12 2021 Lumír Balhar <lbalhar@redhat.com> - 3.10-10
 - Non-existing path in py_reproducible_pyc_path causes build to fail
 Resolves: rhbz#2011056
diff --git a/tests/test_evals.py b/tests/test_evals.py
index 9061e39..f86284d 100644
--- a/tests/test_evals.py
+++ b/tests/test_evals.py
@@ -220,6 +220,24 @@ def test_py_provides_with_evr():
     assert len(lines) == 3
 
 
+def test_python_wheel_pkg_prefix():
+    assert rpm_eval('%python_wheel_pkg_prefix', fedora='44', rhel=None, eln=None) == ['python']
+    assert rpm_eval('%python_wheel_pkg_prefix', fedora='44', rhel=None, eln=None, python3_pkgversion='3.9') == ['python']
+    assert rpm_eval('%python_wheel_pkg_prefix', fedora=None, rhel='1', eln='1') == ['python']
+    assert rpm_eval('%python_wheel_pkg_prefix', fedora=None, rhel='1', eln=None) == ['python3']
+    assert rpm_eval('%python_wheel_pkg_prefix', fedora=None, rhel='1', eln=None, python3_pkgversion='3.10') == ['python3.10']
+    assert rpm_eval('%python_wheel_pkg_prefix', fedora=None, rhel='1', eln=None, python3_pkgversion='3.11') == ['python3.11']
+
+
+def test_python_wheel_dir():
+    assert rpm_eval('%python_wheel_dir', fedora='44', rhel=None, eln=None) == ['/usr/share/python-wheels']
+    assert rpm_eval('%python_wheel_dir', fedora='44', rhel=None, eln=None, python3_pkgversion='3.9') == ['/usr/share/python-wheels']
+    assert rpm_eval('%python_wheel_dir', fedora=None, rhel='1', eln='1') == ['/usr/share/python-wheels']
+    assert rpm_eval('%python_wheel_dir', fedora=None, rhel='1', eln=None) == ['/usr/share/python3-wheels']
+    assert rpm_eval('%python_wheel_dir', fedora=None, rhel='1', eln=None, python3_pkgversion='3.10') == ['/usr/share/python3.10-wheels']
+    assert rpm_eval('%python_wheel_dir', fedora=None, rhel='1', eln=None, python3_pkgversion='3.11') == ['/usr/share/python3.11-wheels']
+
+
 def test_pytest_passes_options_naturally():
     lines = rpm_eval('%pytest -k foo')
     assert '/usr/bin/pytest -k foo' in lines[-1]