diff --git a/macros.python-srpm b/macros.python-srpm
index efe2bba..ecd08e7 100644
--- a/macros.python-srpm
+++ b/macros.python-srpm
@@ -52,6 +52,20 @@
 %py3_other_build /bin/true
 %py3_other_install /bin/true
 
+# Define where Python wheels will be stored and the prefix of -wheel packages
+# - In Fedora we want wheel subpackages named e.g. `python-pip-wheel` that
+#   install packages into `/usr/share/python-wheels`. Both names are not
+#   versioned, because they're used by all Python 3 stacks.
+# - In RHEL we want wheel packages named e.g. `python3-pip-wheel` and
+#   `python3.11-pip-wheel` that install packages into similarly versioned
+#   locations. We want each Python stack in RHEL to have their own wheels,
+#   because the main python3 wheels (which we can't upgrade) will likely be
+#   quite old by the time we're adding new alternate Python stacks.
+# - In ELN we want to follow Fedora, because builds for ELN and Fedora rawhide
+#   need to be interoperable.
+%python_wheel_pkg_prefix python%{?rhel:%{!?eln:%{python3_pkgversion}}}
+%python_wheel_dir %{_datadir}/%{python_wheel_pkg_prefix}-wheels
+
 
 
 # === Macros for Build/Requires tags using Python dist tags ===
diff --git a/python-rpm-macros.spec b/python-rpm-macros.spec
index 1c54152..524c60c 100644
--- a/python-rpm-macros.spec
+++ b/python-rpm-macros.spec
@@ -22,7 +22,7 @@ License:        MIT and Python
 # The macro is defined in python-srpm-macros.
                 %{?load:%{SOURCE102}}
 Version:        %{__default_python3_version}
-Release:        38%{?dist}
+Release:        39%{?dist}
 
 BuildArch:      noarch
 
@@ -95,6 +95,9 @@ install -m 644 compileall2.py %{buildroot}%{_rpmconfigdir}/redhat/
 
 
 %changelog
+* Wed Sep 29 2021 Tomas Orsava <torsava@redhat.com> - 3.9-39
+- Define a new macros %%python_wheel_dir and %%python_wheel_pkg_prefix
+
 * Wed Jul 07 2021 Miro Hrončok <mhroncok@redhat.com> - 3.9-38
 - Introduce %%py3_check_import
 
diff --git a/tests/test_evals.py b/tests/test_evals.py
index a54bb83..b63f4ad 100644
--- a/tests/test_evals.py
+++ b/tests/test_evals.py
@@ -194,6 +194,24 @@ def test_py_provides_with_evr():
     assert len(lines) == 3
 
 
+def test_python_wheel_pkg_prefix():
+    assert rpm_eval('%python_wheel_pkg_prefix', fedora='44', rhel=None, eln=None) == ['python']
+    assert rpm_eval('%python_wheel_pkg_prefix', fedora='44', rhel=None, eln=None, python3_pkgversion='3.9') == ['python']
+    assert rpm_eval('%python_wheel_pkg_prefix', fedora=None, rhel='1', eln='1') == ['python']
+    assert rpm_eval('%python_wheel_pkg_prefix', fedora=None, rhel='1', eln=None) == ['python3']
+    assert rpm_eval('%python_wheel_pkg_prefix', fedora=None, rhel='1', eln=None, python3_pkgversion='3.10') == ['python3.10']
+    assert rpm_eval('%python_wheel_pkg_prefix', fedora=None, rhel='1', eln=None, python3_pkgversion='3.11') == ['python3.11']
+
+
+def test_python_wheel_dir():
+    assert rpm_eval('%python_wheel_dir', fedora='44', rhel=None, eln=None) == ['/usr/share/python-wheels']
+    assert rpm_eval('%python_wheel_dir', fedora='44', rhel=None, eln=None, python3_pkgversion='3.9') == ['/usr/share/python-wheels']
+    assert rpm_eval('%python_wheel_dir', fedora=None, rhel='1', eln='1') == ['/usr/share/python-wheels']
+    assert rpm_eval('%python_wheel_dir', fedora=None, rhel='1', eln=None) == ['/usr/share/python3-wheels']
+    assert rpm_eval('%python_wheel_dir', fedora=None, rhel='1', eln=None, python3_pkgversion='3.10') == ['/usr/share/python3.10-wheels']
+    assert rpm_eval('%python_wheel_dir', fedora=None, rhel='1', eln=None, python3_pkgversion='3.11') == ['/usr/share/python3.11-wheels']
+
+
 def test_pytest_passes_options_naturally():
     lines = rpm_eval('%pytest -k foo')
     assert '/usr/bin/pytest -k foo' in lines[-1]