diff --git a/openbabel.spec b/openbabel.spec
index d135844..44fd2c8 100644
--- a/openbabel.spec
+++ b/openbabel.spec
@@ -119,6 +119,7 @@ Summary: Python wrapper for the Open Babel library
 Requires: %{name}-libs%{?_isa} = %{version}-%{release}
 BuildRequires: python3-devel
 %{?python_provide:%python_provide python3-%{name}}
+Obsoletes: python2-%{name}%{?_isa} < 2.4.1-21
 
 %description -n python3-%{name}
 Python3 wrapper for the Open Babel library.