diff --git a/openbabel.spec b/openbabel.spec
index 9534d67..7b9d4fd 100644
--- a/openbabel.spec
+++ b/openbabel.spec
@@ -5,7 +5,7 @@
 
 Name: openbabel
 Version: 3.1.1
-Release: 11%{?dist}
+Release: 12%{?dist}
 Summary: Chemistry software file format converter
 License: GPLv2
 URL: https://openbabel.org/
@@ -242,6 +242,19 @@ rm -f %{buildroot}%{_libdir}/cmake/openbabel2/*.cmake
 desktop-file-install --dir=%{buildroot}%{_datadir}/applications %{SOURCE1}
 install -Dpm644 babel.png %{buildroot}%{_datadir}/pixmaps/babel.png
 
+# Create profile files
+mkdir -p %{buildroot}%{_sysconfdir}/profile.d
+cat > %{buildroot}%{_sysconfdir}/profile.d/openbabel3.sh <<EOF
+BABEL_LIBDIR=%{_libdir}/%{name}
+export BABEL_LIBDIR
+BABEL_DATADIR=%{_datadir}/%{name}
+export BABEL_DATADIR
+EOF
+cat > %{buildroot}%{_sysconfdir}/profile.d/openbabel3.csh <<EOF
+setenv BABEL_LIBDIR %{_libdir}/%{name}
+setenv BABEL_DATADIR %{_datadir}/%{name}
+EOF
+
 %if 1
 %check
 %define _vpath_builddir %{_target_platform}
@@ -269,6 +282,8 @@ ctest3 -j1 --force-new-ctest-process
 %endif
 
 %files
+%config(noreplace) %{_sysconfdir}/profile.d/openbabel3.sh
+%config(noreplace) %{_sysconfdir}/profile.d/openbabel3.csh
 %{_bindir}/ob*
 %{_bindir}/roundtrip
 %{_mandir}/man1/*.1*
@@ -319,6 +334,9 @@ ctest3 -j1 --force-new-ctest-process
 %{ruby_vendorarchdir}/openbabel.so
 
 %changelog
+* Sun Aug 07 2022 Antonio Trande <sagitter@fedoraproject.org> - 3.1.1-12
+- Add profile file openbabel3.sh (rhbz#2112710)
+
 * Thu Aug 04 2022 Scott Talbert <swt@techie.net> - 3.1.1-11
 - Rebuild with wxWidgets 3.2