diff --git a/0001-build-Replace-Python-distutils-by-sysconfig.patch b/0001-build-Replace-Python-distutils-by-sysconfig.patch
new file mode 100644
index 0000000..310abc9
--- /dev/null
+++ b/0001-build-Replace-Python-distutils-by-sysconfig.patch
@@ -0,0 +1,69 @@
+From 068ce21cee3d726aaf19d0b3a706bda66dd521b2 Mon Sep 17 00:00:00 2001
+From: "Richard W.M. Jones" <rjones@redhat.com>
+Date: Tue, 18 Oct 2022 10:55:22 +0100
+Subject: [PATCH] build: Replace Python distutils by sysconfig
+MIME-Version: 1.0
+Content-Type: text/plain; charset=UTF-8
+Content-Transfer-Encoding: 8bit
+
+This module has been deprecated in Python >= 3.10
+(https://peps.python.org/pep-0632/).  Replace distutils.sysconfig with
+sysconfig which is not quite a drop-in replacement.
+
+This fix is incomplete as we still reference distutils in
+python/setup.py.in.  However that is only used for PIP-style
+distributions (make -C python sdist) which we don't really use or
+recommend.
+
+Thanks: Miro Hrončok
+See-also: https://peps.python.org/pep-0632/
+See-also: https://lists.fedoraproject.org/archives/list/python-devel@lists.fedoraproject.org/thread/N6ITYHLRWIDNYNXGPYG2ZHF3ZLQWZN7L/
+
+Cherry picked from libguestfs commit 26940f64a7406761
+---
+ configure.ac | 16 ++++++++--------
+ 1 file changed, 8 insertions(+), 8 deletions(-)
+
+diff --git a/configure.ac b/configure.ac
+index e65d4a0..b540df7 100644
+--- a/configure.ac
++++ b/configure.ac
+@@ -271,10 +271,10 @@ AS_IF([test "x$enable_python" != "xno"],
+ 
+             AC_MSG_CHECKING([for Python include path])
+             if test -z "$PYTHON_CFLAGS"; then
+-                python_path=`$PYTHON -c "import distutils.sysconfig; \
+-                                         print (distutils.sysconfig.get_python_inc ());"`
+-                python_platpath=`$PYTHON -c "import distutils.sysconfig; \
+-                                             print (distutils.sysconfig.get_python_inc (plat_specific=1));"`
++                python_path=`$PYTHON -c "import sysconfig; \
++                                         print (sysconfig.get_path('include'));"`
++                python_platpath=`$PYTHON -c "import sysconfig; \
++                                             print (sysconfig.get_path('platinclude'));"`
+                 if test "$python_path" = "$python_platpath"; then
+                     PYTHON_CFLAGS=-I$python_path
+                 else
+@@ -294,16 +294,16 @@ AS_IF([test "x$enable_python" != "xno"],
+ 	        PYTHON_INSTALLDIR=
+                 AC_MSG_CHECKING([for Python site-packages path])
+                 if test -z "$PYTHON_INSTALLDIR"; then
+-                    PYTHON_INSTALLDIR=`$PYTHON -c "import distutils.sysconfig; \
+-                                                   print (distutils.sysconfig.get_python_lib(1,0));"`
++                    PYTHON_INSTALLDIR=`$PYTHON -c "import sysconfig; \
++                                                   print (sysconfig.get_path('platlib'));"`
+                 fi
+                 AC_MSG_RESULT([$PYTHON_INSTALLDIR])
+             fi
+ 
+             AC_MSG_CHECKING([for Python extension suffix (PEP-3149)])
+             if test -z "$PYTHON_EXT_SUFFIX"; then
+-                python_ext_suffix=`$PYTHON -c "import distutils.sysconfig; \
+-                                               print (distutils.sysconfig.get_config_var('EXT_SUFFIX') or distutils.sysconfig.get_config_var('SO'))"`
++                python_ext_suffix=`$PYTHON -c "import sysconfig; \
++                                             print (sysconfig.get_config_var('EXT_SUFFIX') or sysconfig.get_config_var('SO'))"`
+                 PYTHON_EXT_SUFFIX=$python_ext_suffix
+             fi
+             AC_MSG_RESULT([$PYTHON_EXT_SUFFIX])
+-- 
+2.37.3
+
diff --git a/hivex.spec b/hivex.spec
index ac2b4d1..a4937c5 100644
--- a/hivex.spec
+++ b/hivex.spec
@@ -11,7 +11,7 @@
 
 Name:           hivex
 Version:        1.3.21
-Release:        11%{?dist}
+Release:        12%{?dist}
 Summary:        Read and write Windows Registry binary hive files
 
 License:        LGPLv2
@@ -27,6 +27,11 @@ Source1:        http://libguestfs.org/download/hivex/%{name}-%{version}.tar.gz.s
 Source2:       libguestfs.keyring
 %endif
 
+# Upstream Python removal of distutils (RHBZ#2155013)
+Patch:          0001-build-Replace-Python-distutils-by-sysconfig.patch
+
+BuildRequires:  make
+BuildRequires:  autoconf, automake, libtool
 BuildRequires:  perl-interpreter
 BuildRequires:  perl-devel
 BuildRequires:  perl-generators
@@ -61,9 +66,8 @@ BuildRequires:  rubygem(rdoc)
 BuildRequires:  readline-devel
 BuildRequires:  libxml2-devel
 %if 0%{verify_tarball_signature}
-BuildRequires: gnupg2
+BuildRequires:  gnupg2
 %endif
-BuildRequires: make
 
 Requires:       %{name}-libs = %{version}-%{release}
 
@@ -199,6 +203,8 @@ ruby-%{name} contains Ruby bindings for %{name}.
 %setup -q
 %autopatch -p1
 
+autoreconf -fi
+
 
 %build
 %configure \
@@ -324,6 +330,10 @@ fi
 
 
 %changelog
+* Tue Jan 03 2023 Richard W.M. Jones <rjones@redhat.com> - 1.3.21-12
+- Upstream fix for Python 3.12 removal of distutils (RHBZ#2155013)
+- Unconditionally run autoreconf.
+
 * Thu Jul 21 2022 Fedora Release Engineering <releng@fedoraproject.org> - 1.3.21-11
 - Rebuilt for https://fedoraproject.org/wiki/Fedora_37_Mass_Rebuild