diff --git a/.gitignore b/.gitignore
index 6539303..58a19c9 100644
--- a/.gitignore
+++ b/.gitignore
@@ -26,3 +26,4 @@ IRanges_1.6.8.tar.gz
 /IRanges_2.16.0.tar.gz
 /IRanges_2.20.0.tar.gz
 /IRanges_2.20.1.tar.gz
+/IRanges_2.22.2.tar.gz
diff --git a/R-IRanges.spec b/R-IRanges.spec
index 5d0241b..0b55e8d 100644
--- a/R-IRanges.spec
+++ b/R-IRanges.spec
@@ -3,8 +3,8 @@
 %global bootstrap 1
 
 Name:             R-%{packname}
-Version:          2.20.1
-Release:          2%{dist}
+Version:          2.22.2
+Release:          1%{dist}
 Summary:          Low-level containers for storing sets of integer ranges
 License:          Artistic 2.0 and Copyright only
 # See https://www.redhat.com/archives/fedora-r-devel-list/2009-April/msg00001.html
@@ -15,7 +15,7 @@ Source0:          http://bioconductor.org/packages/release/bioc/src/contrib/%{pa
 %endif
 BuildRequires:    R-devel >= %{Rvers} tex(latex)
 BuildRequires:    R-methods R-stats R-RUnit R-utils R-stats4 R-BiocGenerics >= 0.25.3
-BuildRequires:    R-S4Vectors-devel >= 0.23.22
+BuildRequires:    R-S4Vectors-devel >= 0.25.14
 # R-GenomicRanges is only needed for check, but it makes a dep loop
 %if %{bootstrap} < 1
 BuildRequires:    R-GenomicRanges
@@ -81,6 +81,10 @@ rm -rf %{buildroot}%{_libdir}/R/library/R.css
 %{_libdir}/R/library/%{packname}/include
 
 %changelog
+* Mon Jun  8 2020 Tom Callaway <spot@fedoraproject.org> - 2.22.2-1
+- update to 2.22.2
+- rebuild for R 4
+
 * Tue Jan 28 2020 Fedora Release Engineering <releng@fedoraproject.org> - 2.20.1-2
 - Rebuilt for https://fedoraproject.org/wiki/Fedora_32_Mass_Rebuild
 
diff --git a/sources b/sources
index 0c703d6..e0efbe2 100644
--- a/sources
+++ b/sources
@@ -1 +1 @@
-SHA512 (IRanges_2.20.1.tar.gz) = 465e18d4624bf997531322b9378e821cb9f9ecda91150347824ad87468f185b13e87c7055165c87c1338bf49f3fa65145956cb27f285e1043e93331af07f1ef8
+SHA512 (IRanges_2.22.2.tar.gz) = cf72853cdbbaaac2fd21e84aaae8dc1b9ef0acb2c8a6a99e575edb558bf2cb465910ac776c2a75b4a494bcb685c155091fdff22d0c5ee8490646d3266671e27a