diff --git a/.gitignore b/.gitignore
index 67eed4b..f181f2e 100644
--- a/.gitignore
+++ b/.gitignore
@@ -11,3 +11,4 @@ GenomicRanges_1.0.7.tar.gz
 /GenomicRanges_1.14.4.tar.gz
 /GenomicRanges_1.16.3.tar.gz
 /GenomicRanges_1.20.3.tar.gz
+/GenomicRanges_1.22.1.tar.gz
diff --git a/R-GenomicRanges.spec b/R-GenomicRanges.spec
index 46b1489..bdb892f 100644
--- a/R-GenomicRanges.spec
+++ b/R-GenomicRanges.spec
@@ -2,8 +2,8 @@
 %global rlibdir %{_libdir}/R/library
 
 Name:             R-%{packname}
-Version:          1.20.3
-Release:          2%{dist}
+Version:          1.22.1
+Release:          1%{dist}
 Summary:          Representation and manipulation of genomic intervals
 
 Group:            Applications/Engineering 
@@ -12,8 +12,8 @@ URL:              http://www.bioconductor.org/packages/release/bioc/html/Genomic
 Source0:          http://www.bioconductor.org/packages/release/bioc/src/contrib/%{packname}_%{version}.tar.gz
 BuildRoot:        %{_tmppath}/%{name}-%{version}-%{release}-root-%(%{__id_u} -n)
 
-Requires:         R-core >= 3.0.0 R-methods R-IRanges >= 2.1.45 R-BiocGenerics >= 0.11.3 R-XVector >= 0.1.3 R-GenomeInfoDb >= 1.1.20 R-S4Vectors >= 0.5.14
-BuildRequires:    R-devel tex(latex) R >= 3.0.0 R-methods R-IRanges-devel >= 2.1.45 R-BiocGenerics >= 0.11.3 R-XVector-devel >= 0.1.3 R-GenomeInfoDb >= 1.1.20 R-S4Vectors-devel >= 0.5.14
+Requires:         R-core >= 3.0.0 R-methods R-IRanges >= 2.3.24 R-BiocGenerics >= 0.16.1 R-XVector R-GenomeInfoDb >= 1.1.20 R-S4Vectors >= 0.8.1
+BuildRequires:    R-devel tex(latex) R >= 3.0.0 R-methods R-IRanges-devel >= 2.3.24 R-BiocGenerics >= 0.16.1 R-XVector-devel R-GenomeInfoDb >= 1.1.20 R-S4Vectors-devel >= 0.8.1
 
 %description
 The ability to efficiently store genomic annotations and alignments is
@@ -62,6 +62,9 @@ rm -rf %{buildroot}
 %{rlibdir}/%{packname}/libs/
 
 %changelog
+* Mon Dec  7 2015 Tom Callaway <spot@fedoraproject.org> - 1.22.1-1
+- update to 1.22.1
+
 * Tue Jun 16 2015 Fedora Release Engineering <rel-eng@lists.fedoraproject.org> - 1.20.3-2
 - Rebuilt for https://fedoraproject.org/wiki/Fedora_23_Mass_Rebuild
 
diff --git a/sources b/sources
index 3c4174a..d79e94b 100644
--- a/sources
+++ b/sources
@@ -1 +1 @@
-9978dcf3b1548aaf114278ac9e785524  GenomicRanges_1.20.3.tar.gz
+7f089a14a684aafcda9f0583eb7ace53  GenomicRanges_1.22.1.tar.gz